報告題目：Radioluminescence Imaging Based Spatiotemporal dosimetry and oximetry for FLASH radiotherapy
報 告 人：張榮曉
報告時間：2021年1月20日9:30-11:30
報告地點：騰訊會議925 189 211
主辦單位：?？茀f、材料科學與技術學院
報告人簡介：
張榮曉，美國達特茅斯學院副研究員。2015年博士畢業于美國達特茅斯學院，2015-2018年在哈佛大學完成住院醫學物理師培訓。2018年，埃默里大學質子中心擔任助理教授、醫學物理師，2020年至今在達特茅斯學院副研究員、臨床物理師。主要從事基于光學的劑量測量與質量保證、蒙特卡羅模擬、人工智能在醫學圖像中的應用、光動力治療等研究，致力于開展臨床科學研究不斷提升放射治療療效。目前已發表80余篇國際學術會議論文/摘要，60余篇學術期刊論文。
報告摘要：
Radiation therapy is anessential component of cancer care and over 14 million people a year, which is50% – 60% of total cancer patients. The capabilities available for cliniciansto localize and deliver precise amounts of radiation to specific anatomies haveimproved dramatically over recent years, due to advances in imaging guidance,treatment planning and dose delivery technologies. However, we are now facing along-lasting bottleneck to further improve the therapeutic ratio, i.e. tumorcontrol vs. normal tissue toxicity. Recent advances in ultra-high doseradiotherapy, abbreviated as FLASH, have shown the potential for reduction inhealthy tissue damage while preserving tumor control. FLASH therapy relies on very highdose rate of > 40Gy/sec with sub-second temporal beam modulation, taking aseemingly opposite direction from the conventional paradigm of fractionatedtherapy. With this, FLASH brings unique challenges to its dosimetry. Whilespatial dose conformity delivered to a target volume has been pushed to itspractical limits with advanced treatment planning and delivery, FLASH RTnecessitates novel spatiotemporal dosimetry techniques. The FLASH effect hasbeen reported mainly based upon phenomenological observations with tissuefunction assays, rather than mechanistic in situ measurements. There areseveral radiobiological hypotheses around the mechanisms for less damage, howeverto date none are directly proven, and indeed the data supporting any mechanismis glaringly absent. The central feature dominating most proposed mechanisms islinked to the fact that oxygen depletion, which is expected to occur rapidly atFLASH dose rates, via oxygen radical production with consumption from oxidationreactions.
