報告題目：Targeted Neuro-modulation by Non-invasive Ultrasound

報告時間：2019年4月22日（周一） 下午14:00

報告人：  Dr. Lei Sun（香港理工大學）

報告地點：明故宮校區9號樓506會議室

主辦單位：機械結構力學及控制國家重點實驗室、航空學院

報告內容簡介：

Capable of non-invasive transmission trough skull with fine focal size (~mm), ultrasonic (US) neuro-modulation is a promising means and a good alternative to existing stimulating strategies. Here we demonstrate precise control of neural activity and signaling through gating mechanosensitive ion channels (such as Piezo1, MscL) by non-invasive ultrasonic stimulation. Our results show when triggered by ultrasound, Piezo1 or MscL was activated to induce reversible neuronal activity (e.g. calcium influx, membrane potential) and significant modifications in signaling (e.g. p-CREB and p-CaMKII upregulation). In addition, the ultrasonic stimulation in M1 area of mouse brain induced excitation of targeted neurons resulting in body movement and neural activation marker protein c-Fos expression level. This study demonstrates the feasibility of targeting ultrasound into deep brain structures non-invasively with brain wide scalability, allowing precise control of local and global neural activity.

報告人簡介：

Dr. Lei SUN received his PhD degree in Bioengineering from Pennsylvania State University in 2004. He was a post-doctoral fellow at the University of Southern California during 2004 to 2008. The he joined the Department of Biomedical Engineering, the Hong Kong Polytechnic University in 2008. Currently he is the associate head and associate professor there. Dr. SUN’s research integrates multi-disciplinary areas of biology, physics and engineering, and studies ultrasound as a non-invasive mechanical wave for therapy and imaging. His current research interests include ultrasound neuro-modulation, ultrasound and photoacoustic molecular imaging and theranostics, and 444ultrasound instrumentation.